NMN for longevity
Grade ANicotinamide Mononucleotide is a direct NAD+ precursor implicated in mitochondrial function, DNA repair, and sirtuin activity.
87/100 Evidence Strength
Why NMN matters for longevity
Nicotinamide Mononucleotide is a direct NAD+ precursor implicated in mitochondrial function, DNA repair, and sirtuin activity.
- Restored NAD+ in aged tissues
- Improved insulin sensitivity in postmenopausal women
- Aerobic capacity improvements (small RCTs)
Typical dose
250–500 mg AM
Best timing
Morning, before training
Evidence grade
Grade A 87/100
Mechanism of action
Phosphorylated nicotinamide ribose converted intracellularly to NAD+ via NMNAT enzymes; supports CD38, SIRT1/3, and PARP-dependent pathways.
Dosage & Timing
Typical
250–500 mg AM
Range
125 mg – 1,000 mg
Timing
Morning, before training
With Food
Not required
Form
Sublingual powder or enteric capsule
Category
Mitochondrial
Reported Benefits
- Restored NAD+ in aged tissues
- Improved insulin sensitivity in postmenopausal women
- Aerobic capacity improvements (small RCTs)
Side Effects
- Mild nausea at high doses
- Flushing (rare)
Contraindications
- Active malignancy (theoretical)
- Pregnancy (insufficient data)
Known Interactions
ResveratrolOften co-stacked; mechanistic synergy via sirtuins.
ChemotherapyAvoid — NAD+ may modulate tumor metabolism.
References
NMN — Frequently Asked Questions
Common questions about dose, benefits, side effects and longevity use of NMN.
What is the typical dose of NMN?+
250–500 mg AM (range 125 mg – 1,000 mg). Morning, before training. Food not required.
How does NMN work in the body?+
Phosphorylated nicotinamide ribose converted intracellularly to NAD+ via NMNAT enzymes; supports CD38, SIRT1/3, and PARP-dependent pathways.
What are the longevity benefits of NMN?+
Nicotinamide Mononucleotide is a direct NAD+ precursor implicated in mitochondrial function, DNA repair, and sirtuin activity. Reported benefits include: Restored NAD+ in aged tissues; Improved insulin sensitivity in postmenopausal women; Aerobic capacity improvements (small RCTs).
What are the side effects of NMN?+
Mild nausea at high doses; Flushing (rare) Avoid in: Active malignancy (theoretical), Pregnancy (insufficient data).
What is NMN commonly stacked with for longevity?+
TMG (trimethylglycine), Resveratrol, Pterostilbene.
Comparison vs Alternatives
All Supplements →| Attribute | NMNThis page | Urolithin A | Creatine Monohydrate |
|---|---|---|---|
| Evidence | Grade A87/100 | Grade B71/100 | Grade A94/100 |
| Category | Mitochondrial | Mitochondrial | Cognition |
| Best for | Restored NAD+ in aged tissues | Improved muscle endurance in middle-aged adults (RCT) | Strength and lean mass |
| Typical dose | 250–500 mg AM | 500 mg AM | 5 g daily |
| Timing | Morning, before training | Morning, with or without food | Any time of day, consistent |
| Form | Sublingual powder or enteric capsule | Capsule (Mitopure / synthetic urolithin A is most-studied) | Micronized powder |
| Action | Current page | View → | View → |