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Metabolic · Reference range

HbA1c

Also reported as: Glycated haemoglobin · A1c · Haemoglobin A1c

The proportion of haemoglobin that has become glycated — a weighted average of blood glucose over the preceding 8–12 weeks.

Lab reference range
< 5.7 %

Below 5.7% normal, 5.7–6.4% prediabetes, 6.5% or above diabetes.

Optimal target
4.8–5.4 %

Observational risk for cardiovascular events and all-cause mortality is lowest in roughly the 5.0–5.4% band, above the level seen in anaemia and below the prediabetic range.

Guideline thresholds from: American Diabetes Association Standards of Care

To convert to mmol/mol, multiply by 10.929.

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Where the thresholds sit

BandRange (%)Note
Low< 4.8 Can reflect anaemia or shortened red-cell lifespan rather than good glucose control.
Optimal4.8–5.4
Normal5.4–5.7
Prediabetes5.7–6.5
Diabetes range> 6.5

Why it matters

The standard measure of chronic glucose exposure, and the one glycaemic number with hard outcome data behind its thresholds. Its value for healthspan is that it integrates over months, so it cannot be gamed by a good day.

What raises it

  • Chronic carbohydrate excess relative to activity
  • Insulin resistance
  • Iron deficiency anaemia — falsely raises HbA1c
  • Prolonged red-cell survival, such as after splenectomy

What lowers it

  • Any intervention that lowers average glucose
  • Haemolysis, blood loss and recent transfusion — falsely lowers HbA1c
  • Pregnancy

How to move it

  1. 1Walk for 10–15 minutes after meals. Post-meal movement blunts the glucose excursion more reliably than almost any other single habit.
  2. 2Build resistance training — muscle is the largest glucose sink in the body.
  3. 3Reduce refined carbohydrate, particularly liquid sugar.
  4. 4Improve sleep. A week of short sleep measurably worsens insulin sensitivity in healthy people.
  5. 5Retest no sooner than 12 weeks — the marker cannot move faster than red cells turn over.

What moves this marker

Interventions on this site with evidence behind them for this specific marker. None of them replaces working out why yours is where it is.

What makes a single reading misleading

  • Unreliable in anaemia, haemoglobinopathies (including sickle-cell trait), recent transfusion, pregnancy and chronic kidney disease.
  • A normal HbA1c can mask large post-meal spikes. Fasting insulin or a CGM shows what it hides.
  • Ethnic differences in glycation mean the same average glucose can produce slightly different HbA1c values.

Sources

Read next

Interpret your whole panelAll biomarkers

Educational only. Reference ranges are not diagnostic thresholds and this page cannot account for your medical history, medication or symptoms. Discuss any result that concerns you with a qualified clinician. See our medical disclaimer.