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Longevity Stack
Interactions Explorer

What to avoid.

Filter peptide drug and stack interactions by category and severity. Pick a peptide to focus on what matters for your cycle.

2 matches
Focus peptide
Retatrutide
Triple GIP/GLP-1/glucagon agonist
Grade A
Contraindications — do not use if
  • Personal or family history of medullary thyroid carcinoma
  • Multiple Endocrine Neoplasia type 2
  • Pregnancy and lactation
  • Prior severe reaction to GLP-1 agonists
Insulin and sulfonylureas
Caution / monitorGlucose & diabetes meds

Risk of hypoglycemia — dose reduction usually required.

Oral medications
Caution / monitorOral drug absorption

Delayed gastric emptying may alter absorption; separate timing for narrow-therapeutic-index drugs.

Interaction categories and severities are inferred from published notes and are not a substitute for a clinician review. Absence of a listed interaction is not evidence of safety — always cross-reference for any drug you take.