Does the eating window have to be in the morning?

Early TRE (8 AM–4 PM) produces stronger insulin sensitivity benefits than late windows, but adherence is the dominant variable. A consistent 10-hour window any time of day captures most of the metabolic upside.

Will TRE cause muscle loss?

Not if protein is adequate (≥1.6 g/kg/day) and resistance training is preserved. The TREAT trial showed lean mass loss only when training stimulus was absent.

Is 16:8 better than 14:10?

Marginally. Most metabolic markers plateau between 12 and 14 hours of fasting. Pushing to 16 hours adds adherence cost without clearly proportional benefit.

Research Library

The synthesized longevity record.

1,200+ peer-reviewed studies indexed, graded and cross-referenced. Updated weekly with the most consequential findings in healthspan science.

Grade ANAD+ · 9 min

NMN vs NR: Which NAD+ Precursor Wins for Adult Restoration?

Head-to-head review of nicotinamide mononucleotide and nicotinamide riboside — pharmacokinetics, NAD+ uplift, human trial endpoints, and dosing strategy.

Grade AFasting · 11 min

Time-Restricted Eating and Metabolic Flexibility: The 2026 Evidence

What 14 years of randomized trials reveal about TRE windows, circadian alignment, insulin sensitivity, and lean mass preservation.

Grade BRapamycin · 14 min

Intermittent Rapamycin in Healthy Adults — The PEARL Trial

Inside the largest randomized trial of low-dose rapamycin for healthspan: dosing schedule, lean-mass and pain outcomes, immune signals, and what it does and does not prove.

Grade BGLP-1 · 13 min

Semaglutide Beyond Weight Loss: Cardiometabolic and Longevity Signals

GLP-1 agonists now have outcome data beyond obesity and diabetes — cardiovascular, renal, hepatic, and emerging neurodegenerative endpoints.